Pathology Handbook

 New search
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # ALL

Posaconazole (Sendaway Test)

Laboratory:Clinical Biochemistry
Test Code:POS
Medicare rebatable:Yes
Specimen Types:Plasma
Container Types:
EDTA 3 mLEDTA 3 mL
Adults Volume or Mass:3 mL
Collection & Request Instructions:Collect pre-dose

Collect samples Pre Dose

Do not use tubes with gel separator.

Assay run 3 x weekly  (Monday, Tuesday & Thursday) - samples must be in the Alfred laboratory by 11AM on each of those day. Results available the following day.

Transport Instructions:Room Temperature
Processing Instructions:Centrifuge
Aliquot
Store frozen
Assay Frequency:3 x weekly (thrice)
External Laboratory:The Alfred Pathology Service (APS)
  External Laboratory details...
External Transport Instructions:Send Frozen on Dry Ice
Method:

LCMSMS

Additional Notes:

Therapeutic Ranges for Posaconazole

 We suggest to monitor Posaconazole trough concentration at steady state (7 days after starting therapy). Levels ≥ 0.7 mg/L are required for prophylaxis and ≥ 1mg/L for invasive fungal infection. 

See also POSACONAZOLE DOSING AND THERAPEUTIC DRUG MONITORING

Reference Interval Source:

Chau M, Kong D, van Hal J et al. Consensus guidelines for optimising antifungal drug delivery and monitoring to avoid toxicity and improve outcomes in patients with haematological malignancy, 2014. Internal Medicine Journal 2014; 1364-1388.