Pathology Handbook

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Itraconazole (Sendaway Test)

Laboratory:

Clinical Biochemistry

Test Code:

ITZ

Medicare rebatable:

Yes

Specimen Types:

Plasma

Container Types:

EDTA 3 mL

Adults Volume or Mass:

3 mL

Collection & Request Instructions:

Collect samples pre dose.

Do not use tubes with gel separator.

Dose information should be provided and length of therapy must be >5 days.

Transport Instructions:

Room Temperature

Processing Instructions:

Centrifuge
Aliquot
Freeze Immediately

Assay Frequency:

3 x weekly (thrice)

External Laboratory:

The Alfred Pathology Service (APS)

External Laboratory details...

Method:

LCMSMS

Additional Notes:

Reference Interval:

Itraconazole (trough) - Localised infection > 0.5 mg/L
- Systemic infection >1.0 mg/L

OH-Itraconazole has similar activity to itraconazole and levels can be added to give the sum of both levels ( in this case therapeutic range recommend > 1.0 mg/L).

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