Pathology Handbook

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Posaconazole (Sendaway Test)

Laboratory:

Clinical Biochemistry

Test Code:

POS

Medicare rebatable:

Yes

Specimen Types:

Plasma

Container Types:

EDTA 3 mL

Adults Volume or Mass:

3 mL

Collection & Request Instructions:

Collect pre-dose

Collect samples Pre Dose

Do not use tubes with gel separator.

Assay run 3 x weekly (Monday, Tuesday & Thursday) - samples must be in the Alfred laboratory by 11AM on each of those day. Results available the following day.

Transport Instructions:

Room Temperature

Processing Instructions:

Centrifuge
Aliquot
Store frozen

Assay Frequency:

3 x weekly (thrice)

External Laboratory:

The Alfred Pathology Service (APS)

External Laboratory details...

External Transport Instructions:

Send Frozen on Dry Ice

Method:

LCMSMS

Additional Notes:

Therapeutic Ranges for Posaconazole

We suggest to monitor Posaconazole trough concentration at steady state (7 days after starting therapy). Levels ≥ 0.7 mg/L are required for prophylaxis and ≥ 1mg/L for invasive fungal infection.

See also POSACONAZOLE DOSING AND THERAPEUTIC DRUG MONITORING

Reference Interval Source:

Chau M, Kong D, van Hal J et al. Consensus guidelines for optimising antifungal drug delivery and monitoring to avoid toxicity and improve outcomes in patients with haematological malignancy, 2014. Internal Medicine Journal 2014; 1364-1388.

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